CDK4 and hepatocellular carcinoma: Subgroup analysis also demonstrated the diagnostic value of TRIM28/H2AX/CDK4 in various important clinical characteristics of HCC, with AUC values of 0.925, 0.932 and 0.929 for T1, respectively; 0.965, 0.959 and 0.952 for T2/3/4, respectively; 0.926, 0.938 and 0.926 for stage I, respectively; and 0.963, 0.954 and 0.949 for stage II/III/IV, respectively (Figure 5A).