CD8A, CD8B, CD19, CD79A, interferon regulatory factor 5, integrin subunit α M, human leukocyte antigen (HLA)-DPB1, HLA-DQB1, HLA-DRA, HLA-DPA1, CD1C, neuropilin 1 and integrin subunit αX were found to be significantly correlated with TRIM28 expression in HCC (Table 2). The gene discussed is CD8B; the disease is hepatocellular carcinoma.