Subsequently, we assessed the TRIM3, TRIM6 and TRIM28 expression profile in normal and HCC tissues collected from TCGA and GEPIA2 dataset cohorts, where the results indicated that TRIM6 and TRIM28 expression was significantly increased in HCC tissues compared with that in normal tissues according to the TCGA database (Figure 1C, Supplementary Figure 1C). This evidence concerns the gene TRIM6 and hepatocellular carcinoma.