TNF and cancer: In another study, Helix aspersa slime inhibited the growth of IGR-39 and SK-MEL-28 melanoma cells, by increasing expression of the cytokine Tumor Necrosis Factor (TNF-α), and inhibiting the transcription process, by blocking transcription Nuclear factor kappa light chain enhancer of activated B cells (NF-κB), that in proper regulation has been linked to cancer progression [55].