In this context, the LSD1 HDM plays a critical role due to its ability to suppress endogenous double stranded RNA (dsRNA) levels and interferon (IFN) responses in tumour cells, as demonstrated by a preclinical study that showed that LSD1 inhibition in tumour cells causes intracellular dsRNA stress and resultant IFN activation and anti-tumour T cell immunity promotion. This evidence concerns the gene KDM1A and neoplasm.