The rationale for why this feature may portend a worse prognosis may be explained by the synergistic effect of liver iron accumulation (leading to increased oxidative stress) and relative tumor iron resistance (likely owing to HAMP/hepcidin downregulation, CDK-1/STAT3 pathway activation, and transferrin receptor-1 upregulation) [34–37]. Here, STAT3 is linked to neoplasm.