Damaged ER-mitochondria signalling is seen in other cell and transgenic mouse models of familial ALS/FTD, such as those involving TAR-DNA binding protein 43kDa (TARDBP), VAPB, Fused in Sarcoma (FUS), superoxide dismutase 1 (SOD1), sigma non-opioid intracellular receptor 1 (SIGMAR1) or TANK binding kinase 1 (TBK1) [1]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.