Indeed, alterations in ER-mitochondria signalling and the VAPB-PTPIP51 interaction have been related to age-related neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s (AD) disease and Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD) [1]. The gene discussed is VAPB; the disease is amyotrophic lateral sclerosis.