CREB1 and heart disorder: ATF/CREB plays an important role in energy metabolism and cell growth[31] and participates in regulating the development of the heart and somatic cells.[40] Our results showed that Atf7 knockdown reduced cardiomyocyte necroptosis induced by pathological stimuli, suggesting that ATF7 functions as a pro‐necroptotic transcription factor during heart disease development.