RIPK1 and neurodegenerative disease: Necroptosis is regulated by a sophisticated cellular signaling network.[9] Under the induction of TNFα, RIPK1 and RIPK3 can phosphorylate each other to form necrosomes.[10] RIPK1 and RIPK3 are phosphorylated to facilitate kinase activity, and mixed lineage kinase domain‐like protein (MLKL) is phosphorylated and activated, which further mediates cell necroptosis.[10] Necroptosis is relevant in ischemic injury and neurodegenerative diseases, and it has become the focus of cell death research in recent years.[11, 12]