It is reported that circFLI1 binds to the FLI1 promoter and induces DNA demethylation, which epigenetically activates FLI1, in breast cancer.[61] Circ‐ENO1 acts as a ceRNA to interact with miR‐22‐3p and upregulate ENO1 expression in lung adenocarcinoma.[62] In this study, we showed that circNOLC1 can upregulate the expression of NOLC1 by maintaining the stability of NOLC1 mRNA through RNA binding protein HuR. This evidence concerns the gene ENO1 and lung adenocarcinoma.