Recent reports have shown that G6PD activity may be affected by numerous factors, such as tumor suppressor p53, p73, PTEN, transcription factor YY1, protein kinase mTOR, and Plk1.[12, 13, 14, 15, 16, 17] However, despite the crucial roles of G6PD and the oxPPP in CRC, their regulatory mechanisms in liver metastases still remain unclear. The gene discussed is G6PD; the disease is colorectal carcinoma.