Moreover, YY1 knockdown with siRNA in HCT116 and LS174T cells (Figure S6E,F, Supporting Information) significantly reduced levels of both circNOLC1 and mature NOLC1 mRNA while inducing variable reductions in the pre‐NOLC1 RNA level (Figure 6E), suggesting that the upregulation of circNOLC1 in CRC cells results at least partially from elevated YY1 expression. The gene discussed is NOLC1; the disease is colorectal carcinoma.