It is reported that circFLI1 binds to the FLI1 promoter and induces DNA demethylation, which epigenetically activates FLI1, in breast cancer.[61] Circ‐ENO1 acts as a ceRNA to interact with miR‐22‐3p and upregulate ENO1 expression in lung adenocarcinoma.[62] In this study, we showed that circNOLC1 can upregulate the expression of NOLC1 by maintaining the stability of NOLC1 mRNA through RNA binding protein HuR. The gene discussed is FLI1; the disease is breast carcinoma.