Upregulation of c‐Met expression in colon cancer cells with overexpression of MACC1 (metastasis‐associated in colon cancer‐1) significantly increased the liver metastasis rate.[28] Sprouty‐2 was found to increase the metastatic potential by regulating the expression of c‐Met in colon cancer cells.[29] Our previous study found that liver and lymph node sinus endothelial cell c‐type lectin (LSECtin) promoted liver metastasis by upregulating c‐Met expression in colon cancer cells.[30]. The gene discussed is MACC1; the disease is colonic neoplasm.