It has been reported that the cellular level of circACC1 modulates both fatty acid β‐oxidation and glycolysis, resulting in profound changes in cellular lipid storage.[21] The circ‐CUX1/EWSR1/MAZ axis is a therapeutic target for aerobic glycolysis and neuroblastoma progression.[55] In this study, we found that circNOLC1 regulates metabolic reprogramming in colon cancer cells by promoting oxPPP reprogramming. Here, CUX1 is linked to malignant colon neoplasm.