STAT3 and cancer: CK2 is a constitutively active serine/threonine kinase, which can trigger hundreds of substrates phosphorylation including Stat3, JAK2, p53, PTEN, RelA/p65, and AKT,[18, 19] consequently, regulates multiple downstream signaling pathways that are involved in diseases development such as diabetes, cardiovascular diseases, angiogenesis, and cancer progression.[20] CK2 regulates tumor progression because it is highly expressed in many types of cancer.[19] However, the effect of CK2 on tumor immune escape is still unclear.