Implanted tumor model analysis showed that ING4 but not F178A mutant significantly inhibited tumor growth and reduced tumor weight (Figure 4I,J), which was accordant with decreased PD‐L1 level (Figure S7A, Supporting Information) and increased cytotoxic T cell activity in tumors (Figure S7B, Supporting Information), suggesting that ING4‐LIR motif was required for inhibition of NSCLC immune escape, which was involved in reduced PD‐L1 level and increased T cell activity. Here, ING4 is linked to non-small cell lung carcinoma.