Although ING4 could suppress tumor immune escape by inducing PD‐L1 autophagic degradation, loss of ING4 protein levels were observed in multiple types of cancer such as lung cancer,[3] hepatocellular carcinoma (HCC),[4] astrocytomas,[5] ovarian,[6] coloncancer,[7] breast cancer,[8, 49] and primary prostate tumors.[50] However, the mechanism of loss of ING4 protein level in tumors is still unclear. This evidence concerns the gene ING4 and hepatocellular carcinoma.