CD274 and cancer: As a tumor suppressor, ING4 plays an important role in regulating cancer cell proliferation, angiogenesis, DNA repair, apoptosis, migration, invasion, and chromatin remodeling.[44] Our previous investigation suggests that ING4 could induce substrate ubiquitination and degradation,[2] while lysosome inhibitor rather than a proteasome inhibitor terminated the effect of ING4‐mediated PD‐L1 degradation, suggesting that ING4 induced PD‐L1 autophagic degradation.