CK2α/CK2α or CK2α/CK2α’ together with two CK2β forms a tetramer that exhibits catalytic activity for targeted substrates.[17] Hundreds of substrates are phosphorylated by CK2 including Stat3, p53, Janus kinase 2 (JAK2), PTEN, RelA, and AKT,[18, 19] leading to regulation of diabetes, cardiovascular diseases, angiogenesis, and tumor progression.[20] CK2 is highly expressed in multiple types of cancer that regulates cancer cell proliferation, apoptosis, invasion, migration, and tumor progression,[19] while the interaction of CK2 with ING4 on tumor immune escape is still unclear. This evidence concerns the gene PTEN and neoplasm.