ING4 is an important tumor suppressor,[44] which could bind to H3K4me3 and induce cell apoptosis in response to genotoxic stress.[46] In addition, ING4 inhibits NFκB‐mediated pro‐inflammatory response,[47] angiogenesis and tumor growth.[48] However, it is unclear the effect of ING4 on tumor immune escape. The gene discussed is NFKB1; the disease is neoplasm.