ING4 (inhibitor of growth 4) is one of the members of inhibitor of growth (ING1‐5) family.[1] As a tumor suppressor, ING4 negatively regulates tumor growth by inhibiting cancer cell proliferation, migration, and invasion,[1, 2] while the loss of ING4 has been observed in multiple types of cancer including lung cancer,[3] hepatocellular carcinoma (HCC),[4] astrocytomas,[5] ovarian,[6] colorectal adenocarcinoma,[7] and breast cacner.[8] However, the effect of ING4 on tumor immune escape is still unclear. This evidence concerns the gene ING1 and hepatocellular carcinoma.