CD274 and neoplasm: As blockade of PD‐1/PD‐L1 immune checkpoint could inhibit tumor immune escape,[14] but it exhibits low response rates for patients.[16] As one of the inhibitors of CK2, TBB induced PD‐L1 autophagic degradation, and combined TBB with PD‐1 mono‐antibody significantly inhibited tumor growth by increasing T cell activity in LLC implanted tumor model.