C3 and amyotrophic lateral sclerosis: In addition, 14 genes (i.e., Anxa2, Bcl2l15, C3, Chodl, Fam135b, Hrk, Lix1, Lrp1b, Moap1, Pcp4, Prph, Rnase4, Scg5, and Scnn1a) were reported as ALS- or MN disease-associated genes in the literature (Benoit et al., 2013; Ghavami et al., 2014; Gros-Louis et al., 2004; Lederer et al., 2007; Li et al., 2013; Orr et al., 2020; Sasongko et al., 2010; Sheila et al., 2019; Shu et al., 2022; Sleigh et al., 2014; Su et al., 2022; Wei et al., 2011; Wu et al., 2019).