To elucidate the potential mechanism leading to β-AR mRNA redistribution in failing cardiomyocytes, we used a recently discovered detubulation agent, imipramine, to remove t-tubules from control cardiomyocytes, to investigate whether t-tubule remodeling, a known feature in failing cardiomyocytes, contributes to β-AR mRNA redistribution post–myocardial infarction. The gene discussed is ADRB2; the disease is myocardial infarction.