Noribogaine has been shown in a drosophila model system to function as a pharmacochaperone and rescue folding deficits in human DAT variants associated with juvenile PD, as well as restore the delivery of DAT to the pre-synaptic terminals of dopaminergic neurons (Kasture et al., 2016; Mazhar Asjad et al., 2017). The gene discussed is SLC6A3; the disease is Parkinson disease.