Interestingly, some ubiquitin ligases are also involved in ferroptosis occurrence (Meng et al., 2022), while myasthenia-specific MAFbx and MuRF1 expression increases with iron accumulation in the skeletal muscle of aging individuals (Bodine and Baehr, 2014; Huang et al., 2021). Here, TRIM63 is linked to Fatigable weakness.