This notion was further supported by the expression pattern of the two phylogenetically and functionally divergent clades of Igfbp1/2/4 and Igfbp3/4/6 (see Pérez-Sánchez et al., 2018), which resulted herein in an enhanced expression of hepatic igfp1a and muscle igfbp3a in HD fish (Tables 3 and 4). This evidence concerns the gene IGFBP3 and Huntington disease.