ANGPT2 and type 2 diabetes mellitus: Due to the contrasting microvascular effects of Ang-1 and Ang-2 upon Tie-2 receptor stimulation, an imbalance of Ang-1 and Ang-2 in T2DM patients will result in disequilibrium in angiogenesis [10, 16, 21–23], leading to exuberant yet dysfunctional neovascularization in the diabetic retinopathy, as well as vascular destabilization as observed in skeletal and cardiac muscle [24].