SLC2A1 and Alzheimer disease: Postmortem human studies have also found reduced GLUT in the brains of patients with Alzheimer’s disease (Harik, 1992; Kyrtata et al., 2021), and that carriers of the apolipoprotein E4 gene, who have a significantly higher risk of developing Alzheimer’s disease, have fewer GLUT3 transporters in the brain than noncarriers (Zhao et al., 2017).