MMP2 and Hepatic fibrosis: Here, we showed the downregulation of MMP2 in the follicular phase in the presence of pro-inflammatory cytokines, which may be responsible for the overexpression and accumulation of collagen type I. Our results suggest that downregulation of MMP2 is necessary to facilitate the progression of fibrosis, and other researchers like Onosuka et al. (54) and Radbill et al. (55) demonstrated similar results in the murine liver fibrosis model.