From the FLOR enrichment analysis, we identified significant terms and pathways related to lipopolysaccharide (LPS) binding and gram-negative bacterium defense, primarily driven by LBP, several members of the cathelicidin family of antimicrobial peptides (CAMP, CATHL1, and CATHL2), and the adhesion G protein-coupled receptor gene ADGRB1. Several studies have suggested that florfenicol helps combat bacterial infection, regulate LPS-induced immune proliferation, and quell host inflammation via these mechanisms in a concentration-dependent manner (69–72). The gene discussed is ADGRB1; the disease is bacterial infectious disease.