Similarly, our data showing increased leptin in circulation in the mouse model of PAH with BMPR2 mutation is consistent with the published data in hypoxia and the monocrotaline mouse model of PH (18), although this has never been confirmed in BMPR2 mutant mice, which have a strong recapitulation of human metabolic features (28, 47, 48). This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.