The innate immune response to viral infections is mediated by the cytosolic DNA-sensing pathway (hsa04623) as is known as cGAS-STING pathway, and amendments in the pathway cascade drive inflammation-driven tumor growth (27) and participate at defense against viral infections (hsa05162, hsa05164, and hsa05167) and at virus-induced carcinogenesis (hsa05203). Here, CGAS is linked to viral infectious disease.