The changes in cytosolic DNA-sensing pathway (hsa04623) catalyzes the synthesis of cyclic dinucleotide cGAMP, which activates stimulator of IFN genes (STING) and mediates inflammation by inducing IFN1 production (IFN1) (22) and allowing innate immune response to infections, inflammation, and cancer (28). The gene discussed is STING1; the disease is cancer.