Tumor necrosis factor (TNF) superfamily member 10 (TNFSF10), known as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or ApoEL, is able to induce cell apoptosis in various types of tumor cells (44) by receptor oligomerization and recruitment of the FADD and caspase 8 and 10 (45). Here, CASP8 is linked to neoplasm.