Our findings indicate that several SOCs exhibited strong signals, including hepatobiliary disorders [ROR(95CI)=1.78 (1.31-2.43)], metabolism and nutrition disorders [ROR(95CI)=1.28 (1.01-1.62)], investigations [ROR(95CI)=1.35 (1.18-1.54)], blood and lymphatic system disorders [ROR(95CI)=7.23 (6.43-8.14)], gastrointestinal disorders [ROR(95CI)=2.01 (1.81-2.22)], and general disorders and administration site conditions [ROR(95CI)=1.53 (1.41-1.67)]. Here, CISH is linked to digestive system disorder.