Besides directly killing cancer cells, SABR simultaneously mobilizes innate and adaptive antitumor immune responses through (1) release of tumor antigens and damage-associated molecular molecules (DAMPs) (2); activation of the dsDNA-cGAS-STING pathway resulting in IFN production and DC maturation to prime tumor-specific T cells (3); secretion of cytokines and chemokines to promote T cell infiltration (6). The gene discussed is CGAS; the disease is neoplasm.