We found 1 ultra-rare (c.460G>A, T154A, AF 0.001%) and 2 rare (c.1397C>G, A466G, AF 0.027%; c.1538G>A, R513H, AF 0.016%) RPA1 heterozygous variants (Supplemental Table 1). This evidence concerns the gene RPA1 and atrial fibrillation.