Hyperlipidemia is caused by stimulation of lipoprotein synthesis and diminished catabolism as a result of decreased hepatic lipoprotein lipase due to hypoalbuminemia and increased intrahepatic expression of proprotein convertase subtilisin/kexin type 9 (PCSK9), which results in degradation of low-density lipoprotein receptor (LDLR), thereby causing impaired low-density lipoprotein (LDL) clearance. This evidence concerns the gene LDLR and hyperlipidemia.