Although, there are conflicting reports for the expression of PTTG1IP in malignant tumours, further assessment of the mechanistic action of the miR-6715b-3p/PTTG1IP axis in correlation with the Siglec-15/Sia axis could shed some light on CRC progression and maybe a promising approach for treatment. The gene discussed is PTTG1IP; the disease is colorectal carcinoma.