Ang4, Clca1, and Retnlb are goblet-cell associated genes that are induced during immune responses, such as bacterial and helminth infections, and are typically stimulated by type 2 and 3 immune cytokines such as IL-4/IL-13 (type 2) and IL-22 (type 3) (10, 11, 14, 15, 32). The gene discussed is IL22; the disease is helminthiasis.