(159) found that the combination of pure iron nanoparticle-mediated MHT in alternating magnetic fields (AMF), local injection of nanoparticle, and systemic injection of anti-CTLA4 antibody inhibited tumor metastasis and increased the memory T cell ratio, thereby inducing a strong and long-lasting anti-tumor immune memory and effectively preventing tumor recurrence. This evidence concerns the gene CTLA4 and neoplasm.