Mice lacking the IL-4 receptor α-chain are protected from kidney fibrosis induced by unilateral ureteral obstruction(UUO) and folic acid, with reduced STAT6 signaling in the kidney and lower numbers of both CD206+ M2 macrophages and CD206+PDGFRβ+ bone marrow-derived fibroblasts (52). This evidence concerns the gene MRC1 and Ureteral obstruction.