Consistent with the metabolic alterations, PD1-deficient T-bet+NK1.1− ILCs have been characterized by an increased expression of IFN-γ and granzyme B and K. In addition, the presence of PD1-deficient T-bet+NK1.1− ILCs has been associated with inhibited growth of melanomas in mice (45). The gene discussed is PDCD1; the disease is melanoma.