When a CXCL13-coupled CpG ODN was applied in mice with 4T1 breast cancer metastasis, it successfully stimulated effector TIL-B cells via the CXCL13-CXC5R interaction, promoted GrB-expressing CTLs, without stimulating the CD20low Breg cells (78). Here, CXCL13 is linked to breast carcinoma.