ICOSLG and head and neck squamous cell carcinoma: However, instead of uncovering a T-cell-driven TIL signature that separates HPV+ from HPV- HNSCC, adjusting the number of TILs revealed a distinct set of B-cell associated genes which are highly expressed in HPV+ HNSCC, including BCL2, ADAM28, CD200, ICOSLG and SPIB (133).