KDR and renal cell carcinoma: Secretion of IL-10 anti-inflammatory cytokines and activation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) for the production of VEGFs (85) by Tregs in renal cell carcinoma, were shown to promote aggressive angiogenesis resulting in cancer cell expansion and metastasis (84, 86, 87).