Secretion of IL-10 anti-inflammatory cytokines and activation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) for the production of VEGFs (85) by Tregs in renal cell carcinoma, were shown to promote aggressive angiogenesis resulting in cancer cell expansion and metastasis (84, 86, 87). The gene discussed is KDR; the disease is hereditary clear cell renal cell carcinoma.