In hypoxic microenvironments, which is a common scenario in cancer cases, the upregulation of genes such as Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1), Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) and Lactate Dehydrogenase A (LDHA) in Tregs, represses the antigen presenting efficacy of type -2 conventional dendritic cells (cDC2) thus, inducing immune tolerance and homeostasis (59). This evidence concerns the gene LDHA and cancer.