Given the important involvement of NLRP3 inflammasome in COVID-19, this article reviews the possible pathways of NLRP3 activation in diabetes mellitus complicated with COVID-19, the pathogenesis, and the intervention drugs and therapeutic methods based on inhibiting NLRP3 inflammasome in diabetes mellitus complicated with COVID-19 (6). The gene discussed is NLRP3; the disease is COVID-19.