CXCL8 and neoplasm: Biochemical signals include the secretion of growth factors (VEGF, EGF, FGF, PDGF), pro-inflammatory cytokines (IL-6, IL-8, TNF) [13] and pro-metastatic chemokines (CXCL8, CCL2, CCL5) [14], among others, that induce tumour proliferation and motility.