CDKN2A and Insulin resistance: In 2017, Aguayo Mazzucato’s experiments demonstrated that insulin resistance in insulin-resistant mouse models could increase the expression level of senescent markers of pancreatic β-cells, such as p16INK4a, IGF-1R, and BAMBI, thereby accelerating the senescence of pancreatic β-cells (Aguayo-Mazzucato et al., 2017).