CDKN2A and Insulin resistance: In studies involving adipose tissue, treatment with a senolytic combination of dasatinib with quercetin (Dasatinib plus Quercetin, D+Q) resulted in decreased expression of p21 and p16 INK4a in adipose tissue, significantly reduced expression of pro-inflammatory cytokines, and improved glucose tolerance and insulin resistance in mice with obesity (Palmer et al., 2019a).