Besides, EX was reported to elongate astrocytic projections in the dentate gyrus and to increase TrkB expression in GFAP-positive cells (Fahimi et al., 2017) while in a PD mouse model, Palasz et al. (2019) showed that treadmill training protects neurons through increase in astrocyte-derived BDNF. This evidence concerns the gene BDNF and Parkinson disease.