Conversely, pathologies associated with endothelial dysfunction, such as diabetes (Navaratna et al., 2011), cerebral ischemia (Bejot et al., 2011), high blood pressure (Monnier et al., 2017b) or rheumatoid arthritis (Pedard et al., 2017) decrease cerebral BDNF expression. The gene discussed is BDNF; the disease is hypertensive disorder.