Neutropenia did not respond to G-CSF, IVIG, prednisone 1–2mg/kg, methylprednisolone 1–2mg/kg), rituximab, cyclosporine, tocilizumab; autologous hematopoietic stem cell transplant (ASCT) performed after persistent neutropenia for 64 days. The gene discussed is CSF3; the disease is neutropenia.