The expression of Pentraxin 3 (Ptx3), a PRR related gene stimulated by tumor necrosis factor and interleukin-1beta, which remains underexploited in PCM, has already been reported to be involved in the P. brasiliensis opsonization by macrophages (Diniz et al., 2004). The gene discussed is TNF; the disease is paracoccidioidomycosis.