To our knowledge, it is the first time that both PRRs Clec4d and Clec4a2 were observed in chronic PCM, although Dectin-3 (Clec4d) expression was demonstrated in vitro in human plasmacytoid dendritic cells (pDCs), where it has been associated to type I IFN and IL-1β secretion (Preite et al., 2018). The gene discussed is CLEC4D; the disease is paracoccidioidomycosis.