Interestingly, the risk allele at the TNFSF15 locus [rs6478109] had significantly different AF in patients with NS vs. cases in our cohort but did not have a significantly different AF when comparing corticosteroid therapy response (SSNS vs. SRNS), suggesting this allele is associated with NS but not a predictor of therapy response. The gene discussed is TNFSF15; the disease is atrial fibrillation.