TLR4 and hyperinsulinemic hypoglycemia, familial, 4: The humoral response is mainly based on the synthesis of antimicrobial peptides (AMPs) in the fat body of the fly regulated by two signalling pathways: the Toll and the immune deficiency (Imd) pathways, which induce the production of Drosomycin and Diptericin (as the main AMP of each pathway), respectively [13, 14].