These genes are enriched in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway, all of which have been proven to be closely related to the pathogenesis of various cancer types (Alzahrani, 2019; Bao et al., 2019; Ediriweera, Tennekoon & Samarakoon, 2019; Eke & Cordes, 2015; Machackova et al., 2020; Paluch, Aspalter & Sixt, 2016). This evidence concerns the gene AKT1 and cancer.