MYCN and neuroblastoma: Thus, co-occurrence analyses of CNA, SNV, and indel signatures revealed that whereas focal amplifications typically found in MYCN-driven neuroblastomas are linked to signs of replication stress and slippage, CNAs in high-risk non-MYCN-amplified neuroblastomas are associated with defective HRR, and chromosome mis-segregation patterns are a general feature of all neuroblastomas across risk groups.