For tumor-related diseases predicted by the DILI_PGS, due to the common abnormal immune and metabolic functions in tumor patients, the immune checkpoint inhibitors (PD1 and PDL1) (Peeraphatdit et al., 2020), biosynthesis drugs that interfere with nucleic acid (methotrexate) (Ebbesen et al., 2017), drugs that affect DNA structure and function (cyclophosphamide) (Ming et al., 2019), small-molecule targeted drugs (gefitinib) (Sugiyama et al., 2015) and other commonly used clinical antitumor drugs (Oun et al., 2018) developed based on this have been widely reported to have more side effects. This evidence concerns the gene CD274 and neoplasm.