Interestingly, we observed that the inhibition of NF-κB using the IKK2 inhibitor VI (IKK2i) in PC3-M and C4–2B-M cells significantly reduced TNF mRNA levels, indicating that NF-κB pathways may play an important role in modulating M. hyorhinis-induced TNF-α expression in PCa cells (Fig. 4G). Here, NFKB1 is linked to posterior cortical atrophy.