The groups of COPD patients and healthy controls differedsignificantly in the genotypes and/or alleles frequencydistributions of SIRT1 (rs3818292), SIRT3 (rs3782116,rs536715), SIRT6 (rs107251), AKT1 (rs2494732), PIK3R1(rs10515070, rs831125, rs3730089), and PTEN (rs701848,rs2735343) (Table 1). The gene discussed is SIRT6; the disease is chronic obstructive pulmonary disease.