Smokingas a major risk factor for COPD provokes oxidative stress,which, in turn, affects PTEN expression (Cai et al., 2022).We investigated two PTEN gene functional polymorphicloci; rs70184 is located in PTEN gene 3′ region and changesbinding sites for hsa-miR-1252 and hsa-miR-1304 miRNA;rs2735343, located in the intronic region, affects binding sitesfor several regulatory proteins. Here, PTEN is linked to chronic obstructive pulmonary disease.