PM20D1 and early-onset autosomal dominant Alzheimer disease: Genetic variants in theASTN2 gene are associated with Alzheimer’s disease (Wang etal., 2015), schizophrenia (Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, 2017),autism (Lionel et al., 2014), and other psychiatric disorders.The gene encoding the protein containing a peptidase domainM20 1 (PM20D1) is associated with Alzheimer’s disease(Sanchez-Mut et al., 2018) and Parkinson’s disease (Rudakouet al., 2021).