Additionally, the genes BAG Cochaperone 3 (BAG3), inositol polyphosphate-5-phosphatase A (INPP5A), seizure related 6 homolog (SEZ6), and intercellular adhesion molecule 5 (ICAM5) are involved in the progression of AD has been proposed in several functional studies using animal models (Hoarau et al., 2011; Paetau et al., 2017; Zhu et al., 2018; Zhou et al., 2020; Zhu et al., 2021). This evidence concerns the gene BAG3 and Alzheimer disease.