IL6 and central nervous system cancer: Cheng W. et al. used eight immune genes with the greatest prognostic value, namely, FOXO3, IL-6, IL-10, ZBTB16, CCL18, AIMP1, FCGR2B, and MMP9, to develop an immune-related risk signature for gliomas that could independently distinguish high-risk patients (Yi et al., 2019).