Jia D. et al identified the genes such as IL-13RA2, CCL2, IL-6, TLR2, COL1A2, TIMP1, THBS1, and SERPINE1 in the TME of glioma patients associated with poor prognosis based on the ESTIMATE algorithm (Jia et al., 2018). This evidence concerns the gene IL13RA2 and central nervous system cancer.