F5 and hyperinsulinemic hypoglycemia, familial, 4: Among the 6 postsurgery bleeding episodes, only 3 were considered as excessive surgery-related bleeds: (i) a total hip prosthesis in a patient with FXI deficiency supplemented with high doses of pd-FXI who required the transfusion of platelets and red blood cells; (ii) a tonsillectomy in a child with combined FV and VIII severe deficiency, followed by bleeding at day 7 postsurgery and treated with FFP and TA; and (iii) a woman with mild FVII deficiency and surgery for an ectopic pregnancy without any factor replacement therapy resulting in hemoperitoneum.