F11 and hyperinsulinemic hypoglycemia, familial, 4: In FXI deficiencies, these 3 parameters also were important for replacement therapy decision-making, but their association was not significant as shown in Figure and the absence of significant difference in the percentage of treated patients with bleeding score ≥4 (6/12, 50%) vs <4 (13/52, 25%) (P = .1574).