PLCG2 and cancer: Revising the other samples with unknown drivers, especially the three with confirmed absence of gene fusions (i.e. sample ID HB08, HD97, HE27; Figures 2B, C), we found a variable number of somatic mutations (range 1–25, Figure 2A); mostly were missense mutations (Supplementary Table 2) and affected genes previously reported in other cancer types, such as UBQLN3, PLCG2, and FANCF genes (Figure 2C).