Additionally, a study of 4,821 participants, comprised of 1,300 PCOS patients with SCH and 3,521 PCOS patients without SCH, found that the HOMA-IR, triglyceride, serum total cholesterol (TC), low density lipoprotein (LDL), fasting blood glucose (FBG), fasting C-peptide (FCP), and prolactin levels were higher, while high-density lipoprotein cholesterol (HDL), luteinizing hormone (LH), and testosterone levels were lower in the SCH patients (Table 1) (19). The gene discussed is PLOD1; the disease is spindle cell hemangioma.