Participants with high serum AlkP levels were typically older, lower education levels, less physical activity, higher BMI, less current smokers, drank less alcohol, lower PIR, had hypertension, CVD, diabetes and hyperlipidemia, higher levels of CRP and liver function-related indicators (ALT, AST and GGT) and lower levels of VD and eGFR. This evidence concerns the gene CRP and diabetes mellitus.